GlycoNet: U of M based GlycoNet investigators identify novel anti-cancer agents
Cancer is the leading cause of death in Canada. According to the Canadian Cancer Society, an estimated 202,400 new cancer cases occurred in Canada in 2016, resulting in over 78,800 deaths. GlycoNet scientists, Drs. Frank Schweizer and Gilbert Arthur, together with a team of University of Manitoba (U of M) researchers, have identified a unique way to potentially treat and cure cancer, using carbohydrate-based antitumor agents.
Increasingly, studies support the idea that cancer stem cells (CSCs) are linked to tumor metastasis and resistance to chemotherapies. Therefore, eliminating CSCs is crucial to successful cancer treatment. In a paper published in the Journal of Medicinal Chemistry, Drs. Schweizer and Arthur, and their U of M collaborators, describe the synthesis of L-sugar analogues of an emerging class of glycolipids called glycosylated antitumor ether lipids (GAELs)